Addressing the key challenges of
treating solid tumors

Unlike other immune cells, our CAR-Macrophages combine a unique set of characteristics, which we believe are the key to success in solid tumor treatment:

  • Recruitment and access to the solid tumor microenvironment with the capacity to selectively destroy cancer cells
  • Ability to survive in the hostile solid tumor setting and maintain an anti-tumor phenotype in the presence of immunosuppressive factors
  • Activation of an adaptive immune response leading to long-term anti-tumor immunity and protection against antigen negative relapse

Two distinct approaches to macrophage-based therapeutics

Carisma’s CAR-Macrophages in action

The word macrophage comes from the Greek terms “makro” meaning big and “phagein” meaning eat. Macrophages are a key player in the innate immune system, with the ability to selectively target and destroy multiple tumor cells over their lifespan. This video shows our CAR-Macrophages (in red) in action against cancer cells (in green).

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