Developing therapies for a wide range
of cancers

Carisma is building a pipeline with an initial focus in oncology aiming to bring the power of cellular immunotherapy to the large number of solid tumor patients in whom other approaches fail. At the start of 2021, Carisma initiated the first ever clinical study of a CAR-Macrophage therapy for patients, achieving a key milestone in the development of this new therapeutic approach, and giving hope to patients living with cancer. In Q4 2023, Carisma initiated the first ever clinical study of a CAR-Monocyte in the solid tumor setting.

Our emerging pipeline of oncology CAR-Ms

CT – 0508 (HER2)

Carisma is developing CT-0508, an ex vivo gene-modified autologous CAR-Macrophage cellular therapy intended to treat solid tumors that overexpress human epidermal growth factor receptor 2 (HER2) metastasis. CT-0508 is in Phase 1 clinical development.

Discovery | Preclinical | Phase 1
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CT – 0508 + Pembro (HER2)

Carisma has initiated a clinical study for CT-0508 in combination with Pembrolizumab. The goal of this study is to assess the potential synergy between CAR-Macrophages and anti-PD1 therapy to deliver additional benefit to patients.

Discovery | Preclinical | Phase 1

CT – 0525 (HER2)

Carisma is developing CT-0525, an ex vivo gene-modified autologous CAR-Monocyte cellular therapy intended to treat solid tumors that overexpress human epidermal growth factor receptor 2 (HER2) metastasis. CT-0525 is in Phase 1 clinical development.

Discovery | Preclinical | Phase 1

CT – 1119 (Mesothelin)

Carisma is developing CT-1119, an ex vivo gene-modified autologous CAR-Monocyte cellular therapy to target mesothelin-positive solid tumors. CT-1119 is in pre-clinical development.

Discovery | Preclinical | Phase 1

In Vivo CAR-Macrophage + mRNA/LNP

Carisma is partnering with Moderna Therapeutics to develop the next generation of macrophage-targeted in-vivo therapies to address multiple cancer targets.

Discovery | Preclinical | Phase 1

Fibrosis and Immunology

Using our macrophage and monocyte ex vivo and in vivo engineering platform, Carisma is pursuing early research and development of multiple assets for the potential treatment of diseases beyond oncology. Carisma’s current lead focus outside of oncology is in liver fibrosis.

Discovery | Preclinical | Phase 1
Research & Development Engine

Powering new discovery

Carisma’s scientists are expanding the functionality of engineered macrophages to increase the number of patients that can potentially benefit from this transformative technology. With research programs targeting liver fibrosis, neurodegeneration and autoimmune disorders, Carisma is pushing the boundaries of what is possible.

We are actively seeking partnerships for the development of complementary therapeutic approaches to explore a broader set of indications and reach more patients.

R & D Engine Discovery Preclinical Phase 1
Liver fibrosis
Discovery | Preclinical | Phase 1
Neurodegeneration
Discovery | Preclinical | Phase 1
Autoimmune diseases
Discovery | Preclinical | Phase 1