Harnessing the power of macrophages
Carisma’s innovative approach has the potential to create life-changing cellular therapies for patients with cancer and other serious disorders.Learn More
We are leveraging the natural power of monocytes and macrophages by engineering them to attack tumors. CAR-Macrophages (chimeric antigen receptor macrophages) can eat away at tumors and lead to long-term anti-tumor immunity, giving patients a promising new long term strategy in the fight against cancer.
Carisma is pioneering the development of CAR-Macrophages, a disruptive approach to immunotherapy. Our technology leverages advances in macrophage biology, chimeric antigen receptor engineering, and adoptive cellular therapy for the treatment of human disease.
By engaging both the innate and adaptive immune systems to launch a multi-pronged attack on tumors, CAR-Macrophages address the key challenges faced by current cell therapies:
Challenge: Tumors control which immune effector cells have access to their microenvironment blocking infiltration of T and NK cells.
Solution: Macrophages are actively recruited into tumors traveling down a chemokine gradient.
Challenge: An immunosuppressive tumor microenvironment shuts down infiltrating immune cells.
Solution: CAR-Macrophages are locked into an anti-tumor, or M1, phenotype, and drive T cell recruitment and immune activation of the tumor.
Challenge: Significant cell-to-cell heterogeneity within a tumor mass, allowing for the development of resistance to single-antigen targeted therapies.
Solution: Macrophages are professional antigen presenting cells, capable of activating the patient’s own adaptive immune system against multiple tumor-specific antigens present in the tumor mass.
At Carisma, our pipeline includes multiple CAR-Macrophages designed to target solid tumors by engineering a patient’s own immune cells, giving hope to patients and their families.
If you or your family member would like more information, please learn more about our active and upcoming clinical trials.